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Last Updated on November 13, 2023


Palmoplantar psoriasis is a type of skin condition that mainly affects the skin on your hands and feet. It can look different, appearing as a mix of forms, like pustular or hyperkeratotic. Palmoplantar pustulosis, also known as pustular psoriasis, is another condition where small, sterile pustules are a vital sign. However, both conditions can cause significant problems in how your hands and feet work and last a long time. The situation impacts your life significantly, making it harder to do things. Treating this type of psoriasis has been challenging, but new research on biological treatments gives hope for better results.

What is Palmoplantar Psoriasis?

Psoriasis, a chronic autoimmune disease, has long been a subject of intense scientific scrutiny. However, this condition presents lesions on the palms of the hands and the soles of the feet, adding an extra layer of complexity to an intricate puzzle.

However, researchers are now uncovering the immune system’s role in causing the inflammatory response. This newfound understanding will pave the way for targeted therapies to recalibrate the immune system, providing a more precise and practical approach to treatment.

The Use of Biologic Drugs

One of the most promising frontiers in psoriasis research is the advent of biological therapies. Unlike traditional treatments that broadly suppress the immune system, biologics zero in on specific components that fuel the inflammatory process.

For palmoplantar psoriasis patients, this means a potential game-changer. However, biologics such as adalimumab, infliximab, and ustekinumab have shown remarkable efficacy in clinical trials, offering hope for those who have experienced limited success with conventional treatments.

Light Therapy For Palmoplantar Psoriasis

Phototherapy, or light therapy, has long been a cornerstone in psoriasis management. However, recent advancements in this field have led to the development of targeted phototherapy devices, allowing for a more focused and tailored approach.

In the case of palmoplantar psoriasis, where lesions can be remarkably stubborn, targeted phototherapy offers a beacon of hope. However, by delivering specific wavelengths of light to affected areas, these devices minimize collateral damage to healthy skin while maximizing the therapeutic impact on psoriatic lesions.

Genetic Predisposition

The enigma of psoriasis lies in its external manifestations and the underlying genetic factors predisposing individuals to the condition. Nonetheless, advances in genomics have enabled researchers to unravel the genetic code associated with psoriasis, opening avenues for personalized medicine.

By identifying specific genetic markers, scientists are working towards developing treatments that address the unique genetic profile of each patient. This precision medicine approach holds immense promise for psoriasis on hands and feet, where a one-size-fits-all strategy often falls short.

The Use of Microbiome

The human microbiome, a bustling community of microorganisms inhabiting our skin and gut, is crucial in maintaining health and preventing disease. However, researchers are now exploring the intricate interplay between the microbiome and psoriasis, seeking to harness its therapeutic potential.

In palmoplantar psoriasis, where the skin’s microbiome is significantly altered, interventions to restore microbial balance may prove transformative. Probiotics, prebiotics, and microbiome-targeted therapies are emerging as novel approaches to modulate the microbiome and alleviate psoriatic symptoms.

Beyond the Skin: Addressing the Emotional Toll

While the physical manifestations of psoriasis are evident, the emotional toll it takes on patients is often underestimated. Moreover, living with a chronic condition can lead to feelings of isolation, anxiety, and depression. Recognizing the holistic impact of this condition, researchers increasingly focus on interventions that address the disease’s physical and emotional aspects.

Psychodermatology, a field that explores the intricate connection between the mind and skin, is gaining prominence in psoriasis care. Therapeutic approaches that integrate psychological support with traditional treatments aim to enhance overall well-being and empower patients to navigate the challenges posed by palmoplantar psoriasis.

A Collaborative Future

As we stand on the cusp of a new era in psoriasis research, collaboration emerges as a critical driver of progress. The kinship between dermatologists, immunologists, geneticists, and psychologists is essential in comprehensively addressing the multifaceted nature of palmoplantar psoriasis.

Patient advocacy groups and support networks also play a pivotal role, amplifying the voices of those affected and fostering a sense of community. However, through shared experiences and collective efforts, the journey towards effective treatments and, ultimately, a cure for this psoriasis type becomes a collaborative endeavor.

Is Palmoplantar Psoriasis a Disability?

Palmoplantar psoriasis may be mild and manageable for some individuals with topical or other therapies. However, in more severe cases where the condition is widespread, persistent, and unresponsive to treatment, it can substantially impact daily activities, including work and personal life.

In some cases, individuals with severe psoriasis on hands and feet may experience limitations in mobility, discomfort while standing or walking, and challenges with manual tasks due to lesions on the hands. These factors could affect one’s ability to perform certain job functions or engage in specific activities.

Lifestyle Modifications

Body Nourishment

Sure, kale smoothies have their moment, but proper nourishment goes beyond trendy superfoods. You need to find a balance that works for you. Embrace a rainbow of fruits and vegetables, savor whole grains, and befriend lean proteins. But don’t forget the occasional indulgence – a piece of dark chocolate or that guilty pleasure snack. Moderation is the key.

Timely Sleep

In a world that glorifies hustle culture, sleep often takes a backseat. However, it’s a non-negotiable pillar of well-being. Create a sleeping place – dim the lights, reduce screens before bedtime, and let your sleep be as peaceful as your morning coffee ritual. It will work great wonders for your body and mind.


Hydration goes beyond the mere act of consuming eight glasses a day; it transforms into a mindful practice. Ensure your water bottle is within reach, take a sip when your body signals, and witness the graceful rhythm of hydration. Your skin, energy levels and overall well-being will express gratitude for this uncomplicated yet impactful adjustment to your lifestyle.

Breathable Clothing

Your wardrobe can be your ally. Opt for breathable fabrics that won’t irritate your skin. Loose, comfortable clothing can be a game-changer. Your skin deserves to be dressed for success, too.

Desk Yoga

Who says yoga is only for yoga mats? Desk yoga is a thing. Stretch those arms, roll those shoulders, and do a seated twist. It’s like a mini-vacation for your muscles. Psoriasis blues, meet your match.

Stress Less: Mindfulness Matters

In the chaos of life, find your Zen. Mindfulness isn’t about meditation marathons. It’s about small moments – savoring your morning coffee, enjoying a meal without distractions, or taking a deep breath. Stress less, live more.

Tech Timeout

We’re all hooked on gadgets, but they can suck energy out of us. Pick a time to unplug, an hour before bed or during meals.


In conclusion, the landscape of psoriasis research is evolving, offering newfound hope and optimism for those grappling with this condition. From targeted therapies and advanced phototherapy to personalized medicine and microbiome modulation, the arsenal against this challenging condition is expanding.

As we navigate the exciting developments on this scientific frontier, let us embrace the spirit of collaboration and resilience. Together, researchers, healthcare providers, and patients can illuminate the path forward, bringing us closer to a future where palmoplantar psoriasis is not just managed but conquered. The light at the end of the tunnel is becoming brighter, and with each breakthrough, we move one step closer to a world where psoriasis is a chapter of the past.


MetroBoston Clinical Partners is a well established and experienced research center in the greater Boston area. Under the leadership of qualified physicians and medical professionals, we coordinate a range of clinical research trials in Dermatology and Internal Medicine.

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